Developing new antibody-based treatments for antibiotic-resistant bacterial infections
Official title: Structural Biology Core
Funded at Scripps Research Institute, the · NIH-11082430 · Data updated 2026-11-12
This study is working on new treatments to help your immune system fight tough infections caused by bacteria that don't respond to regular antibiotics, using special vaccines and therapies that target the bacteria's surface.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 9, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $362,000 |
| NIH project number | 5P01AI172525-03 |
| Project ID | NIH-11082430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections caused by antibiotic-resistant bacteria or those at high risk of such infections.
✕Less likely to help
Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
What this research studies
This research focuses on creating innovative immunotherapies that target the surface structures of bacteria, specifically their glycans, to combat antibiotic-resistant infections. By developing novel antibody-based vaccines and therapeutics, the project aims to enhance the immune response against dangerous bacteria such as Staphylococcus aureus, Klebsiella pneumoniae, and Neisseria gonorrhea. The research employs advanced techniques like high-throughput x-ray crystallography to analyze how these antibodies interact with bacterial glycans, which will inform the design of more effective treatments. Patients may benefit from new therapies that could provide alternatives to existing antibiotics.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking treatments for patients suffering from infections caused by antibiotic-resistant bacteria.
How similar studies have gone: Previous research has shown promise in developing antibody-based therapies for bacterial infections, indicating a potential for success in this novel approach.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Wilson, Ian a — Scripps Research Institute, the
- Study coordinator: Wilson, Ian a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.