Developing new antibiotics to fight drug-resistant bacterial infections
De Novo Synthesis, and Functional and Structural Characterization of Novel Aminoglycoside Analogues to Bypass Resistance Mechanisms and Optimize Selectivity
This study is working on developing new antibiotics to help fight tough infections caused by bacteria that don't respond to many current treatments, aiming to create options that are safer and more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10676201 on NIH RePORTER |
What this research studies
This research focuses on creating new aminoglycoside antibiotics to combat multidrug-resistant Gram-negative bacteria, which are increasingly resistant to current treatments. The team will use innovative medicinal chemistry and carbohydrate synthesis techniques to design and test these new drugs. By employing advanced methods like cryo-electron microscopy, they aim to understand the structure of these antibiotics and how they can effectively target resistant pathogens. The goal is to discover new antibiotic options that are both effective and less toxic for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by multidrug-resistant Gram-negative bacteria.
Not a fit: Patients with infections caused by bacteria that are not resistant or those who do not respond to aminoglycoside antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by resistant bacteria, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in developing new antibiotics using similar innovative approaches, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Kirby, James E — Beth Israel Deaconess Medical Center
- Study coordinator: Kirby, James E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.