Developing mRNA vaccines to stimulate immune responses against HIV
Official title: Self-amplifying mRNA-based vaccines to elicit VRC01-class bnAbs
Funded at Fred Hutchinson Cancer Center · NIH-11092358 · Data updated 2026-11-12
This study is testing new mRNA vaccines designed to boost the immune system's ability to fight HIV by focusing on specific parts of the immune cells that make antibodies, and it's aimed at helping people who are looking for better ways to protect themselves against the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 30, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $163,398 |
| NIH project number | 3U19AI174242-03S1 |
| Project ID | NIH-11092358 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals at risk of HIV infection or those who are HIV-positive and seeking innovative treatment options.
✕Less likely to help
Patients who are not at risk for HIV or those who are already receiving effective treatment may not benefit from this research.
What this research studies
This research focuses on creating self-amplifying mRNA vaccines that aim to enhance the immune response against HIV by targeting specific B cell receptors. The approach involves using two different immunogens designed to activate and mature these receptors, which are crucial for producing effective antibodies against the virus. Initially, the study will compare the immune responses generated by these mRNA vaccines with those produced by traditional protein-based vaccines in preclinical models. If successful, the mRNA vaccines will be manufactured for clinical trials in humans.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines against HIV, potentially improving prevention and treatment options for patients.
How similar studies have gone: Previous research has shown promise in using mRNA technology for vaccine development, indicating potential success for this novel approach.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Stamatatos, Leonidas — Fred Hutchinson Cancer Center
- Study coordinator: Stamatatos, Leonidas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.