Developing mRNA-based vaccines for HIV
Official title: cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of mRNA, Lipid Nanoparticle Based HIV Immunogens
Funded at Duke University · NIH-11042021 · Data updated 2026-11-12
This study is working on new mRNA vaccines to help fight HIV, and it's designed for people who want to see better options for preventing this virus, as it aims to create safe and effective vaccines that can boost the immune response.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 30, 2023 |
| Project end | March 28, 2027 |
| Funding year | 2024 |
| Award (this year) | $595,226 |
| NIH project number | 75N93022D00003-P00001-759302300001-1 |
| Project ID | NIH-11042021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk for HIV or those living with HIV who may benefit from new vaccine options.
✕Less likely to help
Patients who are not at risk for HIV or those who have already been effectively treated with existing therapies may not receive direct benefits from this research.
What this research studies
This research focuses on the development and production of mRNA-based vaccines aimed at combating HIV. It involves creating and testing immunogens, which are substances that provoke an immune response, using advanced manufacturing processes that comply with regulatory standards. The project includes stages such as small-scale production, preclinical testing, and preparation for clinical trials, ensuring that the vaccines are safe and effective for human use. Patients may benefit from the innovative approaches taken to enhance vaccine efficacy and stability.
Why it matters
Potential benefit: If successful, this research could lead to effective vaccines that significantly reduce the incidence of HIV infections.
How similar studies have gone: Previous research in mRNA vaccine development has shown promising results, particularly in the context of other infectious diseases, indicating a strong potential for success in this area.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Beres, Wendell — Duke University
- Study coordinator: Beres, Wendell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.