Developing mRNA-based vaccines for HIV
Official title: cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of mRNA, Lipid Nanoparticle Based HIV Immunogens
Funded at Duke University · NIH-10927030 · Data updated 2026-11-12
This study is working on new mRNA vaccines to help prevent and treat HIV, using special tiny particles to deliver the vaccine effectively, and it aims to eventually test these vaccines in people to improve options for those living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 30, 2023 |
| Project end | March 28, 2027 |
| Funding year | 2023 |
| Award (this year) | $6,174,301 |
| NIH project number | 75N93022D00003-0-759302300001-1 |
| Project ID | NIH-10927030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals at high risk for HIV infection or those living with HIV seeking new treatment options.
✕Less likely to help
Patients who are not at risk for HIV or those who have already achieved viral suppression may not receive direct benefits from this research.
What this research studies
This research focuses on the development and manufacturing of mRNA vaccines aimed at combating HIV. It involves creating and testing immunogens, which are substances that provoke an immune response, using lipid nanoparticles to enhance delivery. The project encompasses all stages from small-scale production to preclinical testing, ultimately leading to clinical trials for potential vaccines. Patients may benefit from advancements in HIV prevention and treatment through innovative vaccine technologies.
Why it matters
Potential benefit: If successful, this research could lead to effective vaccines that significantly reduce the risk of HIV infection.
How similar studies have gone: Previous research has shown promise in using mRNA technology for vaccine development, particularly in other viral infections, indicating a potential for success in this area as well.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Beres, Wendell — Duke University
- Study coordinator: Beres, Wendell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.