Developing models to understand and prevent congenital cytomegalovirus transmission
Model Systems Core (MODS Core)
This study is looking at how cytomegalovirus (CMV) can impact children's health, especially in causing birth defects and brain issues, and it's using monkeys to help find ways to create better vaccines and prevention methods.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10874235 on NIH RePORTER |
What this research studies
This research focuses on understanding how cytomegalovirus (CMV) affects children's health, particularly its role in causing birth defects and brain damage. The team is creating preclinical models using rhesus monkeys to study CMV transmission and disease, which will help in developing effective vaccines. By analyzing how CMV interacts with host cells and the placenta, researchers aim to uncover critical insights that could lead to better prevention strategies. The work involves advanced technologies to decode gene expression patterns related to CMV spread.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women or families with a history of congenital CMV infection or related birth defects.
Not a fit: Patients who are not pregnant or do not have a history of CMV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that prevents congenital CMV transmission, significantly improving child health outcomes.
How similar studies have performed: Other research has shown promise in using nonhuman primate models to study viral infections, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Permar, Sallie R. — Weill Medical Coll of Cornell Univ
- Study coordinator: Permar, Sallie R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.