Developing models to test cancer drugs with a functioning immune system
ELABORATION AND USE OF SYNGENIC PRE-CLINICAL MODELS FOR CANCER DRUG DEVELOPMENT
This study is looking at new ways to test cancer treatments that work with the immune system, so we can find better therapies for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leidos Biomedical Research, INC. NIH-funded |
| Lab location | 1 site (Frederick, United States) |
| Project ID | NIH-10502661 on NIH RePORTER |
What this research studies
This research focuses on creating and utilizing syngeneic model systems to evaluate and test anti-cancer agents while maintaining an intact immune system. This approach is particularly important for immuno-oncology agents, which cannot be effectively tested in traditional models that use immunocompromised animals. By using these models, researchers aim to better understand how these treatments interact with the immune system and improve their effectiveness against cancer. Patients may benefit from advancements in cancer therapies that are more accurately tested in these models.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with various types of cancer who are seeking innovative treatment options.
Not a fit: Patients who are not currently diagnosed with cancer or those who have conditions unrelated to cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that harness the body's immune system.
How similar studies have performed: Other research has shown promise in using similar syngeneic models for cancer drug development, indicating a potential for success in this approach.
Where this research is happening
Frederick, United States
- Leidos Biomedical Research, INC. — Frederick, United States (Active)
Researchers
- Principal investigator: Dmitrovsky, Ethan — Leidos Biomedical Research, INC.
- Study coordinator: Dmitrovsky, Ethan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.