Developing models to study uterine cancers and improve treatment options
Official title: PDX Modeling Core
Funded at Dana-Farber Cancer Inst · NIH-11070333 · Data updated 2026-11-12
This study is working on creating special models of endometrial cancer using samples from patients to better understand the disease and find new treatments that can help boost the body's immune response against the cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $369,987 |
| NIH project number | 5P01CA269021-02 |
| Project ID | NIH-11070333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with uterine cancers, particularly those with endometrial cancer.
✕Less likely to help
Patients with cancers other than uterine cancers may not receive direct benefits from this research.
What this research studies
This research focuses on creating and maintaining preclinical models of uterine cancers, specifically endometrial cancer, using patient-derived xenografts (PDX) and genetically engineered mouse models. The team, led by experts in oncology and model development, aims to explore innovative treatment strategies by targeting replication stress and enhancing anti-tumor immunity. Patients' tumor samples will be used to generate models that closely mimic the original cancer, allowing for better understanding and testing of potential therapies. The research will also involve assessing the genetic characteristics of these models to ensure they accurately represent the patient's cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with uterine cancers.
How similar studies have gone: Previous research has shown success in using patient-derived models to study various cancers, indicating a promising approach for this project.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Liu, Joyce — Dana-Farber Cancer Inst
- Study coordinator: Liu, Joyce
Related research
Other NIH-funded projects on the same topics.
-
Helping young people with cancer understand their genetic risks
This study is creating a special program to help teenagers and young adults with hereditary cancer risks learn about their health and make smart choices, while also supporting their families along the way.
-
Core administrative hub for a multifaceted cancer center program
A large, international cancer research program at Dana-Farber aims to advance a curative strategy for multiple myeloma by coordinating translational research, clinical trials, and data analysis.
-
Automated, interactive lab tool to define radiation targets in cancer care
Aims to make it easier and safer to outline the area to treat in radiation therapy for cancers by using smart software and a patient-friendly interface.
-
Cancer Atlas Network data hub to share big cancer data
A national project helps researchers store, harmonize, and share large cancer data collections so doctors and scientists can learn from many patients.
-
Bridge-building cancer research partnership for education, outreach, and science
A joint effort between UMass Boston and Harvard Cancer Consortium to accelerate cancer research and education by connecting lower-resourced institutions with a leading cancer center.
-
NexTGen: Next-Generation T cell therapy for childhood cancers
A charity-friendly overview: researchers at Dana-Farber are developing advanced engineered T-cell therapies to treat pediatric solid cancers like brain tumors and sarcomas.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.