Developing models to study uterine cancers and improve treatment options
PDX Modeling Core
This study is working on creating special models of endometrial cancer using samples from patients to better understand the disease and find new treatments that can help boost the body's immune response against the cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11070333 on NIH RePORTER |
What this research studies
This research focuses on creating and maintaining preclinical models of uterine cancers, specifically endometrial cancer, using patient-derived xenografts (PDX) and genetically engineered mouse models. The team, led by experts in oncology and model development, aims to explore innovative treatment strategies by targeting replication stress and enhancing anti-tumor immunity. Patients' tumor samples will be used to generate models that closely mimic the original cancer, allowing for better understanding and testing of potential therapies. The research will also involve assessing the genetic characteristics of these models to ensure they accurately represent the patient's cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with uterine cancers, particularly those with endometrial cancer.
Not a fit: Patients with cancers other than uterine cancers may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with uterine cancers.
How similar studies have performed: Previous research has shown success in using patient-derived models to study various cancers, indicating a promising approach for this project.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Liu, Joyce — Dana-Farber Cancer Inst
- Study coordinator: Liu, Joyce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.