Developing models to study and treat nervous system disorders
IDD Models Core
This study is exploring how certain genetic and epigenetic disorders affect the nervous system by using special stem cells and advanced techniques, with the goal of finding new ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11132934 on NIH RePORTER |
What this research studies
The IDD Models Core focuses on creating and analyzing human stem cell and rodent models to investigate conditions affecting the nervous system. This research involves studying molecular pathways and cellular interactions that are disrupted in genetic and epigenetic disorders. By utilizing patient-specific induced pluripotent stem cells and advanced gene editing techniques, the core aims to develop innovative tools for understanding these disorders and testing potential therapies. Additionally, it supports preclinical studies to identify effective treatments and biomarkers for nervous system conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic or epigenetic disorders affecting the nervous system.
Not a fit: Patients with non-genetic nervous system disorders or those not affected by IDD conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies and diagnostic tools for patients with nervous system disorders.
How similar studies have performed: Other research has shown success in using stem cell models and gene editing to study nervous system disorders, indicating a promising approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Svaren, John P — University of Wisconsin-Madison
- Study coordinator: Svaren, John P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.