Developing methods to create diverse three-dimensional molecular structures for drug discovery
Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular Diversification
This study is exploring new ways to change the shapes of molecules to help create better medicines, aiming to find new treatments for different health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | City College of New York NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11086109 on NIH RePORTER |
What this research studies
This research focuses on creating new methods to manipulate the three-dimensional structures of molecules, which is crucial for drug development. By using specific organometallic compounds in chemical reactions, the team aims to produce a variety of single-enantiomer drug candidates that can be tested for their biological effectiveness. The approach involves introducing stereochemistry to molecules before forming final structures, allowing for the rapid generation of diverse libraries of potential new drugs. This innovative methodology could lead to the discovery of new treatments for various medical conditions.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions that currently lack effective treatments or those who may benefit from new drug candidates being developed.
Not a fit: Patients with conditions that are already well-managed by existing therapies may not see direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective drug treatments for patients.
How similar studies have performed: Other research has shown success in using similar chemical approaches to develop new drug candidates, indicating a promising avenue for further exploration.
Where this research is happening
New York, United States
- City College of New York — New York, United States (Active)
Researchers
- Principal investigator: Biscoe, Mark Roger — City College of New York
- Study coordinator: Biscoe, Mark Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.