Developing methods to analyze genetic data across different ages and tissues
Official title: Integrative Analysis Methods for the dGTEx Initiative
Funded at University of Chicago · NIH-10990871 · Data updated 2026-11-12
This study is looking at how our genes change as we grow and how these changes can affect our health, using smart computer tools to help find important genes in both kids and adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 2, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $611,365 |
| NIH project number | 1U01MH139345-01 |
| Project ID | NIH-10990871 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of all ages, particularly those with a family history of genetic disorders or developmental conditions.
✕Less likely to help
Patients with no genetic predisposition to the conditions being studied may not receive direct benefits from this research.
What this research studies
This research focuses on creating innovative methods and tools to analyze genetic data from the Developmental Genotype-Tissue Expression (dGTEx) initiative and related studies. It aims to map genetic variations that affect gene expression across various developmental stages and tissue types. By employing advanced machine learning techniques, the research will identify risk genes and their causal effects in both children and adults. This integrative approach will enhance our understanding of how genetic factors influence health throughout different life stages.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of genetic risk factors for diseases, ultimately enhancing prevention and treatment strategies for patients.
How similar studies have gone: Previous research using similar integrative analysis methods has shown promise in identifying genetic risk factors, indicating that this approach has the potential for success.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Chen, Lin — University of Chicago
- Study coordinator: Chen, Lin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.