Developing low-cost devices for generating nitric oxide gas for medical use
Optimization of Cu(II)-ligand catalysts, membrane materials, and coatings for O2-tolerant, portable, and low-cost electrochemical nitric oxide generation devices/catheters
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11019769
This study is working on making easy-to-use and affordable devices that produce a helpful gas called nitric oxide, which can improve treatments for lung problems and help keep catheters safe from infections and clots.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11019769 on ClinicalTrials.gov |
What this research studies
This research focuses on creating portable and affordable devices that generate nitric oxide (NO) gas, which has important therapeutic applications in treating lung conditions and preventing infections. The approach involves using a novel electrochemical method to produce high-purity NO gas from nitrite ions, utilizing Cu(II)-ligand complexes. This method aims to improve the delivery of NO for inhalation therapy and to coat intravenous catheters to reduce infection and clotting risks. Patients may benefit from enhanced treatments for respiratory diseases and improved safety in catheter use.
Who could benefit from this research
Good fit: Ideal candidates include patients with chronic respiratory conditions such as cystic fibrosis, tuberculosis, or COVID-19, as well as those who require intravenous catheterization.
Not a fit: Patients who do not have respiratory conditions or do not require catheterization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and accessible treatments for patients with respiratory diseases and those requiring intravenous catheters.
How similar studies have performed: Previous research has shown promise in using nitric oxide for therapeutic purposes, indicating that this approach could be a significant advancement in treatment options.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEHNERT, NICOLAI — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: LEHNERT, NICOLAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections