Developing long-lasting buprenorphine treatments for opioid addiction
Official title: Long acting biodegradable buprenorphine depots
Funded at Purdue University · NIH-10908653 · Data updated 2026-11-12
This study is testing a new way to deliver buprenorphine, a medication that helps people recover from opioid addiction, by creating a longer-lasting version that means you won't have to take it as often, and it's designed to be safe for the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,114,179 |
| NIH project number | 5UG3DA059270-02 |
| Project ID | NIH-10908653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are currently undergoing treatment for opioid use disorder or are at risk of opioid addiction.
✕Less likely to help
Patients who are not struggling with opioid addiction or who are not interested in medication-assisted treatment may not benefit from this research.
What this research studies
This research focuses on creating a new biodegradable delivery system for buprenorphine, a medication used to help individuals overcome opioid addiction. The goal is to develop a longer-acting formulation that can improve patient adherence to treatment by reducing the frequency of dosing. The project will involve a pilot clinical trial to test the pharmacokinetics of this new formulation in healthy volunteers, aiming to ensure that it releases medication effectively over an extended period. By utilizing established biocompatible polymers, the research seeks to streamline the regulatory process for bringing this new treatment to patients.
Why it matters
Potential benefit: If successful, this research could provide a more effective and convenient treatment option for individuals struggling with opioid addiction.
How similar studies have gone: Previous research has shown success with similar biodegradable drug delivery systems, indicating a promising approach for this treatment.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Otte, Andrew — Purdue University
- Study coordinator: Otte, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.