Developing Lasting Protection Against Coronaviruses
Programming Long-lasting Immunity to Coronaviruses (PLUTO)
['FUNDING_P01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11123392
This project aims to create new vaccines that offer strong, long-lasting protection against many types of coronaviruses, including those like SARS-CoV-2.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11123392 on ClinicalTrials.gov |
What this research studies
This project seeks to understand how our bodies develop strong and lasting protection against coronaviruses, especially after getting sick or vaccinated. Researchers are looking closely at immune cells, called B cells, to learn how they remember past infections and vaccinations. This knowledge will help them design new vaccines that can protect against a wide range of coronaviruses, not just one specific type. The goal is to create 'variant-proof' vaccines that offer broad protection against future coronavirus threats.
Who could benefit from this research
Good fit: Patients who have previously been infected with coronaviruses or received coronavirus vaccines may be ideal candidates for future studies related to understanding immune responses.
Not a fit: Patients without a history of coronavirus infection or vaccination may not directly benefit from studies focused on existing immune responses.
Why it matters
Potential benefit: If successful, this work could lead to new vaccines that provide long-term, widespread protection against current and future coronavirus strains, reducing the impact of future pandemics.
How similar studies have performed: While individual components of coronavirus immunology have been studied, this program aims for a comprehensive and novel approach to design broadly protective vaccines.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMON, VIVIANA A — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SIMON, VIVIANA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.