Developing lab models to understand and treat childhood cystic kidney diseases
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vitro Bioassay and Model Development Resource
This study is working on new ways to understand and treat Childhood Cystic Kidney Diseases by creating lab models that mimic the condition, so researchers can find better treatments and help kids with this serious illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10884926 on NIH RePORTER |
What this research studies
This research focuses on creating in vitro models to study Childhood Cystic Kidney Diseases (CCKDs), which are serious conditions with limited treatment options. By defining the signaling pathways that lead to cyst formation, the research aims to identify potential therapeutic targets. The project will utilize advanced techniques such as organoid cultures and biosensors to visualize cellular changes and test new treatments. This resource center will also standardize methods and provide essential tools to researchers, making it easier to conduct studies on CCKDs.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with cystic kidney diseases.
Not a fit: Patients with kidney diseases unrelated to cystic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for childhood cystic kidney diseases, improving outcomes for affected patients.
How similar studies have performed: Other research has shown promise in using in vitro models and CRISPR technology for studying kidney diseases, indicating a potential for success in this approach.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Parant, John M — University of Alabama at Birmingham
- Study coordinator: Parant, John M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.