Developing KNX100 to help with opioid withdrawal symptoms
Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program.
This project is developing a new medication called KNX100 to help people manage the difficult symptoms of opioid withdrawal.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kinoxis Therapeutics Pty LTD NIH-funded |
| Lab location | 1 site (Camberwell, Australia) |
| Project ID | NIH-11161503 on NIH RePORTER |
What this research studies
We are working on a new medication, KNX100, which has shown promise in animal models for reducing opioid withdrawal symptoms. This medication targets a specific system in the brain to help ease discomfort. Our next steps involve carefully testing KNX100 in people to make sure it is safe and well-tolerated. This initial testing is crucial to see if it can move forward to larger studies that will confirm its effectiveness.
Who could benefit from this research
Good fit: Patients who are experiencing or anticipate opioid withdrawal symptoms may be ideal candidates for future stages of this research.
Not a fit: Patients not experiencing opioid withdrawal symptoms would not directly benefit from this specific treatment.
Why it matters
Potential benefit: If successful, KNX100 could offer a new way to reduce the severe physical and emotional distress experienced during opioid withdrawal.
How similar studies have performed: KNX100 is a novel small molecule, and while preclinical studies have shown promise, its effectiveness in humans is currently untested.
Where this research is happening
Camberwell, Australia
- Kinoxis Therapeutics Pty LTD — Camberwell, Australia (Active)
Researchers
- Principal investigator: Alsop, Hugh William — Kinoxis Therapeutics Pty LTD
- Study coordinator: Alsop, Hugh William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.