Developing inhibitors to combat drug-resistant bacteria
Transport Mechanisms and Inhibition of Efflux Pumps in Pathogenic Organisms
This study is looking at new ways to help antibiotics work better against tough bacteria like Staphylococcus aureus by blocking the pumps that make these bacteria resistant, so patients can have more effective treatment options for their infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11052077 on NIH RePORTER |
What this research studies
This research focuses on creating innovative protein-based inhibitors that target and block efflux pumps in drug-resistant bacteria, specifically Staphylococcus aureus. These efflux pumps are responsible for expelling antibiotics from bacterial cells, making infections harder to treat. By understanding how these pumps work and designing specific inhibitors, the research aims to enhance the effectiveness of existing antibiotics. Patients may benefit from new treatment options that can overcome antibiotic resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by methicillin-resistant Staphylococcus aureus (MRSA).
Not a fit: Patients with infections caused by bacteria that do not utilize efflux pumps for antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore the effectiveness of antibiotics against resistant bacterial infections.
How similar studies have performed: Previous research has shown promise in targeting efflux pumps, indicating that this approach may lead to significant advancements in treating antibiotic-resistant infections.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Traaseth, Nathaniel J. — New York University
- Study coordinator: Traaseth, Nathaniel J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.