Developing inhibitors to block a key protein involved in cancer and autoimmune diseases
Targeting the IKK-Binding Domain of NEMO for Inhibitors Discovery
This study is looking at a protein called NEMO that is involved in inflammation and diseases like autoimmune disorders and cancer, and the researchers are trying to create new medicines that can block its activity to help people with these health issues feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10465104 on NIH RePORTER |
What this research studies
This research focuses on targeting the NEMO protein, which plays a crucial role in activating pathways linked to inflammation, autoimmune diseases, and cancer. By inhibiting the interaction between NEMO and specific kinases, the researchers aim to develop small molecule inhibitors that could effectively block these pathways. The project employs advanced structural and computational methods to design and test these inhibitors, with the goal of creating effective treatments for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancer or autoimmune diseases who may benefit from novel therapeutic approaches.
Not a fit: Patients with conditions unrelated to cancer or autoimmune diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat cancer and autoimmune diseases by targeting the NEMO protein.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for therapeutic development, indicating potential for success in this approach.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Pellegrini, Maria Margherita — Dartmouth College
- Study coordinator: Pellegrini, Maria Margherita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.