Developing immune-compatible stem cells for eye diseases
Alloimmune-compatible stem cells for ocular diseases
['FUNDING_R01'] · SCHEPENS EYE RESEARCH INSTITUTE · NIH-11047948
This study is working on creating special stem cells that can be used to treat eye diseases without being rejected by the body’s immune system, making it easier and faster for patients to get the help they need.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCHEPENS EYE RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11047948 on ClinicalTrials.gov |
What this research studies
This research focuses on creating induced pluripotent stem cells (iPSCs) that are universally compatible with the immune system, specifically for treating various ocular diseases. The approach involves engineering these stem cells to express human leukocyte antigen class 1 (HLA-I) molecules in a way that prevents immune rejection, allowing for their use as an off-the-shelf solution for patients. By using innovative techniques, the researchers aim to eliminate the need for patient-specific cell generation, which is currently time-consuming and costly. This could significantly enhance the availability of regenerative therapies for eye conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from ocular diseases who may benefit from regenerative therapies using stem cells.
Not a fit: Patients with ocular diseases that do not respond to stem cell therapies or those who are not eligible for cell-based interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with a readily available source of stem cells for regenerative treatments of ocular diseases, potentially improving vision and quality of life.
How similar studies have performed: Other research has shown promise in using immune-compatible stem cells for various applications, indicating that this approach could lead to significant advancements in ocular treatments.
Where this research is happening
BOSTON, UNITED STATES
- SCHEPENS EYE RESEARCH INSTITUTE — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAUHAN, SUNIL K — SCHEPENS EYE RESEARCH INSTITUTE
- Study coordinator: CHAUHAN, SUNIL K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.