Developing imaging tools to understand B cells in multiple sclerosis
Imaging B cells in the brain and beyond: developing an immuno-PET toolbox to improve understanding and treatment of multiple sclerosis
This study is looking at new ways to see certain immune cells in the brain that are important for understanding and treating multiple sclerosis, so we can better tailor treatments to help patients who might benefit the most.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10844395 on NIH RePORTER |
What this research studies
This research focuses on improving the understanding and treatment of multiple sclerosis (MS) by developing advanced imaging techniques to visualize B lymphocytes in the brain and other areas. The project aims to create novel positron emission tomography (PET) tracers that can specifically target B cells, which play a crucial role in MS pathology. By tracking these cells, the research seeks to provide valuable insights into patient responses to anti-B cell therapies and enhance treatment monitoring. This approach could help identify which patients are most likely to benefit from specific therapies, ultimately leading to more personalized treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who may benefit from anti-B cell therapies.
Not a fit: Patients with other neurological disorders or those not diagnosed with multiple sclerosis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies for multiple sclerosis, improving patient outcomes and treatment efficacy.
How similar studies have performed: While some preliminary evaluations of PET tracers for B cells in MS have been conducted, this research aims to develop novel approaches that have not yet been tested.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: James, Michelle Louise — Stanford University
- Study coordinator: James, Michelle Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.