Developing human antibodies to fight a dangerous mosquito-borne virus
Human Monoclonal Antibodies for Encephalitic Alphaviruses
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10875511
This study is looking for new ways to help protect people from Eastern equine encephalitis, a serious virus spread by mosquitoes, by developing special antibodies that can fight the virus and keep it from causing harm.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10875511 on ClinicalTrials.gov |
What this research studies
This research focuses on the Eastern equine encephalitis virus (EEEV), a serious mosquito-borne virus that can cause severe brain infections in humans. The project aims to identify and develop highly effective human monoclonal antibodies that can neutralize the virus and potentially protect against its harmful effects. Researchers will use advanced techniques, including next-generation sequencing, to isolate these antibodies and understand how they work in the body. The ultimate goal is to create a treatment that can be delivered effectively to the brain to combat this virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with EEEV or are at high risk of infection due to exposure to mosquito habitats.
Not a fit: Patients who have not been exposed to EEEV or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a targeted treatment for EEEV infections, significantly reducing mortality and long-term neurological damage.
How similar studies have performed: While research on monoclonal antibodies for viral infections has shown promise, this specific approach targeting EEEV is relatively novel and untested.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CROWE, JAMES E — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: CROWE, JAMES E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Alphavirus Infections