Developing gene therapy to reduce brain inflammation in Alzheimer's disease
The development of gene therapeutic approaches to suppress cerebral inflammation in dementia
This study is exploring new ways to use gene therapy to help reduce brain inflammation in people with Alzheimer's disease, and it will test these methods in rats to see if they can improve learning, memory, and overall brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rosalind Franklin Univ of Medicine & Sci NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project ID | NIH-10524978 on NIH RePORTER |
What this research studies
This research focuses on creating new gene therapy methods to target and reduce inflammation in the brains of individuals with Alzheimer's disease (AD). By using advanced gene transfer techniques, the study aims to inhibit the function of inflammasomes, which are key players in the inflammatory response associated with AD. The researchers will test these methods in a rat model that mimics AD, assessing their effects on learning, memory, and brain health. This innovative approach seeks to provide a more effective treatment option for patients suffering from this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's disease by directly targeting inflammation in the brain.
How similar studies have performed: While gene therapy for Alzheimer's is still emerging, there have been promising results in related studies targeting inflammation in neurodegenerative diseases.
Where this research is happening
North Chicago, United States
- Rosalind Franklin Univ of Medicine & Sci — North Chicago, United States (Active)
Researchers
- Principal investigator: Marr, Robert Anthony — Rosalind Franklin Univ of Medicine & Sci
- Study coordinator: Marr, Robert Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.