Developing gene editing tools for marmosets to study brain diseases
Tools for gene editing in marmosets
This study is working on developing new gene editing tools for marmosets to help researchers better understand brain diseases, and the goal is to create special stem cells from marmoset embryos that can be shared with other scientists for more research.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10877523 on NIH RePORTER |
What this research studies
This research focuses on creating new gene editing tools specifically for marmosets, a type of primate that is valuable for studying neurodevelopmental diseases. The team aims to derive new pluripotent stem cell lines from marmoset embryos, which will allow for better modeling of these diseases. By collaborating with experts in IVF and stem cell technology, the researchers hope to produce genetically modified marmosets that can help advance our understanding of neurodegenerative disorders. The new cell lines will be made available to the broader research community to facilitate further studies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals affected by neurodevelopmental disorders or those interested in genetic research involving primates.
Not a fit: Patients with conditions unrelated to neurodevelopmental disorders or those not involved in genetic research may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding and treating neurodevelopmental diseases.
How similar studies have performed: Previous research has shown success in using gene editing tools in other primate models, indicating potential for this approach in marmosets.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wang, Xiaoqin — Johns Hopkins University
- Study coordinator: Wang, Xiaoqin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.