Developing dyes to track single molecules in live cells
Photoactivatable Fluorophores for High-Throughput Multiplexed Tracking of Single-Molecules in Live Cells
This study is all about developing special dyes that can be turned on by light to help scientists see and follow different parts of living cells without harming them, which could lead to better understanding of how cells work and respond to injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami Coral Gables NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11023104 on NIH RePORTER |
What this research studies
This research focuses on creating synthetic dyes that can be activated by light to track multiple components within live cells simultaneously. By using mild green light, these dyes will minimize damage to the cells while allowing precise localization and tracking of individual molecules at the nanometer level. The approach combines advanced imaging techniques to provide detailed insights into cellular processes, which could enhance our understanding of cell function and injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve cellular dysfunction or injury, such as neurodegenerative diseases or cancer.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular mechanisms and improving treatments for various cellular injuries.
How similar studies have performed: Previous research has shown promise in using similar photoactivatable techniques for cellular imaging, indicating potential for success in this novel approach.
Where this research is happening
Coral Gables, United States
- University of Miami Coral Gables — Coral Gables, United States (Active)
Researchers
- Principal investigator: Raymo, Francisco M — University of Miami Coral Gables
- Study coordinator: Raymo, Francisco M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.