Developing durable dental materials to prevent tooth decay and fractures.
Novel polymeric materials with improved durability in the oral environment: tailoring responses to host and bacterial enzymes with anti-proteolytic and ecology-based antimicrobial approaches.
This study is working on new dental materials that are stronger and last longer, especially for people who might not have easy access to dental care, so you can enjoy better dental treatments that need fewer replacements.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10881727 on NIH RePORTER |
What this research studies
This research focuses on creating new dental materials that are more durable and resistant to decay and fractures, particularly in underserved populations. By targeting specific bacterial enzymes that contribute to dental issues, the study aims to enhance the longevity of dental restorations. The approach involves designing specialized monomers that inhibit harmful bacteria and stabilize collagen in dental materials, potentially reducing the need for frequent replacements. Patients can benefit from improved dental treatments that last longer and require fewer interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for dental caries, particularly those who have had multiple dental restorations or belong to underserved populations.
Not a fit: Patients who do not have dental restorations or those with no history of dental caries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dental materials that significantly reduce the frequency of restoration replacements, saving patients time and money.
How similar studies have performed: Previous research has shown promise in developing antimicrobial dental materials, indicating that this approach has potential for success.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Pfeifer, Carmem S. — Oregon Health & Science University
- Study coordinator: Pfeifer, Carmem S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.