Developing drugs to inhibit sialidases that affect inflammation
Official title: Acquisition of a flash chromatography and HPLC preparative system
Funded at Cleveland State University · NIH-10794678 · Data updated 2026-11-12
This study is looking for new ways to help people with chronic inflammation, like those with sepsis, by creating medicines that block certain enzymes that can make inflammation worse.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $76,593 |
| NIH project number | 3R15GM144881-01S1 |
| Project ID | NIH-10794678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory disorders, such as sepsis or other related diseases.
✕Less likely to help
Patients with acute inflammatory conditions that do not involve sialidase activity may not benefit from this research.
What this research studies
This research focuses on creating effective inhibitors for sialidases, enzymes that remove sialic acid from glycoproteins, which can influence inflammation and immune responses. By understanding how these enzymes function, the research aims to develop new treatments for conditions linked to chronic inflammation, such as sepsis. The approach involves using advanced chromatography techniques to analyze and purify potential drug candidates that can effectively inhibit sialidases. Patients may benefit from new therapeutic options that target the underlying mechanisms of their inflammatory disorders.
Why it matters
Potential benefit: If successful, this research could lead to new medications that better manage chronic inflammatory conditions and improve patient outcomes.
How similar studies have gone: Previous research has shown promise in developing sialidase inhibitors, but this specific approach is novel and aims to improve upon existing methods.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Sun, Xue-Long — Cleveland State University
- Study coordinator: Sun, Xue-Long
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.