Developing Cell Models to Understand HIV and Substance Use
Research Support Core B: Primary Cell, Biomimetic, and iPSC-derived Cell Models
['FUNDING_P30'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11141584
This core facility creates specialized cell models and tests to help scientists understand how drugs like cocaine and opioids affect HIV in the body.
Quick facts
| Phase | ['FUNDING_P30'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11141584 on ClinicalTrials.gov |
What this research studies
Understanding how HIV stays hidden in the body, especially when someone also uses substances, is very challenging because there are so few infected cells and it's hard to get enough tissue samples. This project provides advanced cell models, including those grown from patient tissues and stem cells, to mimic how HIV behaves in the brain, gut, and immune system. It also offers sensitive tests to measure how substance use impacts hidden HIV in patient samples. These tools help researchers explore how different drugs change HIV's behavior in various cell types and tissues.
Who could benefit from this research
Good fit: Patients living with HIV who also use substances, or those interested in contributing biological samples to advance HIV research, might be ideal candidates for related studies supported by this core.
Not a fit: Patients who do not have HIV or do not use substances would likely not directly benefit from this specific line of research.
Why it matters
Potential benefit: This work could lead to a better understanding of how substance use complicates HIV, potentially paving the way for new treatments to clear the virus from the body.
How similar studies have performed: This core provides essential tools and models that build upon established cellular and molecular biology techniques to support novel investigations into HIV and substance use.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARN, JONATHAN — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: KARN, JONATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus