Developing biomarkers to identify aggressive prostate cancer
Core-Biomarker Development Laboratory
This study is working to help men with localized prostate cancer by finding better ways to tell which cancers are slow-growing and which are more aggressive, so they can get the right treatment based on their individual risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-10911313 on NIH RePORTER |
What this research studies
This research focuses on improving the clinical management of localized prostate cancer by developing biomarkers that can distinguish between indolent and aggressive forms of the disease. The team will utilize proteogenomic approaches to identify molecular features in prostate fluids and tumor tissues, which will aid in the early detection of aggressive cancer types. The study aims to validate existing urine-based biomarkers and create new ones for better risk stratification, particularly for patients with high-grade lesions that are not visible on MRI. By enhancing the accuracy of cancer diagnosis, this research seeks to ensure that patients receive appropriate treatment based on their specific cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are men who have been newly diagnosed with localized prostate cancer and are at risk for aggressive disease.
Not a fit: Patients with advanced prostate cancer or those who do not have localized disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment decisions for men with prostate cancer, potentially improving survival rates.
How similar studies have performed: Other research has shown promise in using biomarkers for cancer detection, indicating that this approach has potential for success.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Boutros, Paul Christopher — Old Dominion University
- Study coordinator: Boutros, Paul Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.