Developing biomarkers for hereditary neuropathy with liability to pressure palsies.
Biomarker development in patients with HNPP
This study is looking for ways to track how hereditary neuropathy with liability to pressure palsies (HNPP) changes over time using safe and simple tests, like special imaging and skin samples, so that doctors can better understand the condition and find effective treatments without needing to do painful nerve biopsies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10758521 on NIH RePORTER |
What this research studies
This research focuses on patients with hereditary neuropathy with liability to pressure palsies (HNPP), a condition caused by a genetic deletion affecting nerve function. The study aims to develop non-invasive biomarkers using quantitative magnetic resonance imaging (qMRI) and human skin biopsies to monitor disease progression and treatment effects. By identifying reliable measures of axonal loss, the research seeks to improve clinical trial outcomes for potential therapies. This approach allows for longitudinal monitoring without the need for repeated invasive nerve biopsies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hereditary neuropathy with liability to pressure palsies.
Not a fit: Patients with other forms of neuropathy or those without a diagnosis of HNPP may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment options for patients with HNPP.
How similar studies have performed: Previous research has shown promise in developing biomarkers for other neuropathies, suggesting potential success for this novel approach.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Chen, Yongsheng — Wayne State University
- Study coordinator: Chen, Yongsheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.