Developing antibody treatments for a dangerous viral infection
Antibody-based therapeutic strategy for New World mammarenavirus hemorrhagic fever
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10975931
This study is working on new treatments using special antibodies to help fight infections from a virus that can cause serious illness, aiming to stop the virus from entering human cells and keeping people safe from getting sick.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10975931 on ClinicalTrials.gov |
What this research studies
This research focuses on creating new antibody-based therapies to combat New World mammarenavirus infections, which can lead to severe hemorrhagic fever. The approach involves targeting a specific receptor on human cells that the virus uses to enter, thereby preventing the virus from infecting the cells. Researchers have developed a chimeric antibody that has shown promise in laboratory models by blocking the virus's entry and providing protection against the disease. The goal is to advance these therapies for potential use in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to or are at risk of infection from New World mammarenaviruses.
Not a fit: Patients who are not at risk of exposure to New World mammarenaviruses or those with other unrelated viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for patients infected with New World mammarenaviruses, significantly improving survival rates.
How similar studies have performed: Previous research has shown success in developing antibody therapies for other viral infections, suggesting a promising potential for this approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENICHET, MANUEL L — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: PENICHET, MANUEL L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.