Developing antibodies to combat Hendra and Nipah viruses
Project 2 - Vanderbilt University
This study is looking for special antibodies in blood samples from people that can help fight off Hendra and Nipah viruses, which can make both animals and humans very sick, with the hope of developing new treatments for those infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10581502 on NIH RePORTER |
What this research studies
This research focuses on isolating and characterizing human monoclonal antibodies (mAbs) that can effectively neutralize Hendra and Nipah viruses, which are zoonotic pathogens causing severe illness in both domestic animals and humans. The approach involves collecting blood samples from patients to identify naturally occurring mAbs that bind to specific viral proteins. These antibodies will be tested for their ability to prevent or treat infections, with the ultimate goal of advancing promising candidates into clinical trials for human use.
Who could benefit from this research
Good fit: Ideal candidates for participation would include individuals who have been exposed to Hendra or Nipah viruses or those who are at high risk of exposure due to their occupation or location.
Not a fit: Patients who are not at risk of exposure to Hendra or Nipah viruses or those with pre-existing immunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral treatments for Hendra and Nipah virus infections in humans.
How similar studies have performed: Previous research has shown promise in developing monoclonal antibodies for other viral infections, indicating potential success for this approach.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Crowe, James E — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Crowe, James E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.