Developing antibodies that work better with changes in pH
Official title: Engineering and Characterization of pH dependent Antibodies
Funded at Northern Illinois University · NIH-10974952 · Data updated 2026-11-12
This study is exploring how to make antibodies that can adjust their actions based on the acidity in the body, which could lead to better treatments for patients by making these antibodies work more effectively in different conditions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern Illinois University NIH-funded |
| Lab location | 1 site (De Kalb, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $415,329 |
| NIH project number | 1R15GM155846-01 |
| Project ID | NIH-10974952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require antibody-based therapies for conditions such as cancer or other diseases where antibody function is critical.
✕Less likely to help
Patients who do not require antibody therapies or those with conditions unrelated to antibody function may not benefit from this research.
What this research studies
This research focuses on engineering antibodies that can change their behavior based on pH levels, which could enhance their effectiveness in various medical applications. By introducing specific acidic residues, the researchers aim to create antibodies that can better regulate their interactions with antigens, potentially leading to improved therapies. The project will involve detailed characterization of these antibodies to understand how they function in different pH environments. Patients may benefit from advancements in antibody-based treatments that are more responsive to the body's changing conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective antibody therapies that adapt to the body's pH levels, improving treatment outcomes for patients.
How similar studies have gone: While the approach of engineering pH-dependent antibodies is innovative, similar strategies in antibody design have shown promise in other research, suggesting potential for success.
Where this research is happening
-
Northern Illinois University
De Kalb, United States Active
Researchers
- Principal investigator: Horn, James R. — Northern Illinois University
- Study coordinator: Horn, James R.
Related research
Other NIH-funded projects on the same topics.
-
Molecular heat sensors to measure tiny biomolecule reactions
A new, low-sample calorimetry platform uses a fluorescent heat sensor to measure heat changes in biomolecule interactions with picomole quantities, helping researchers study binding and reaction mechanisms.
-
Word Learning and Vocabulary Development in Blind Children
This grant will study how blind and sighted children learn new words and grow their vocabularies to better tailor education for blind students.
-
How blind children learn words and build vocabulary
Comparing how blind and sighted children ages 5–12 learn words and grow their vocabularies.
-
Investigating how blind children learn words and develop vocabulary
This study looks at how blind children, ages 5 to 12, learn new words and build their vocabulary differently than sighted kids, and it aims to find better ways to help them learn language skills.
-
How blind children learn words and develop vocabulary
This study looks at how not being able to see affects how blind children learn new words compared to sighted children, and it aims to find better ways to help blind kids build their vocabulary.
-
Examining how a brief attention-based intervention affects fear responses.
This study is testing a new method called the Attention Training Technique to see if it can help people with PTSD and anxiety who haven't found relief from regular treatments by focusing on how they manage fear.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.