Developing animal models to better understand cystic fibrosis
Animal Models Core
This study is using ferrets and pigs to better understand cystic fibrosis, a genetic disease that affects the lungs, so researchers can find new and better ways to treat and prevent it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10892135 on NIH RePORTER |
What this research studies
This research focuses on creating and utilizing animal models, specifically ferrets and pigs, to study cystic fibrosis (CF), a genetic disease that severely impacts multiple organs, particularly the lungs. By replicating key features of human CF in these animals, researchers aim to gain insights into the disease's progression and the underlying mechanisms that lead to airway infections and inflammation. The project seeks to address current limitations in existing animal models, which do not fully mimic the human condition, thereby enhancing the development of more effective treatments and preventive strategies for CF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis or those who are carriers of CFTR mutations.
Not a fit: Patients with conditions unrelated to cystic fibrosis or those without CFTR mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and preventive measures for patients suffering from cystic fibrosis.
How similar studies have performed: Previous research has shown success in using animal models to study cystic fibrosis, but this approach with ferrets and pigs is relatively novel and aims to fill existing gaps.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Stoltz, David a — University of Iowa
- Study coordinator: Stoltz, David a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.