Developing algorithms to analyze gene expression data in Alzheimer's disease
Geometric structures guided learning model and algorithms for bulk RNAseq data analysis
['FUNDING_R01'] · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · NIH-10894919
This study is looking at how to better understand gene activity in brain tissue from people with Alzheimer's disease, using smart computer techniques to pinpoint important genes that could help us find new treatments just for you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NORTH CAROLINA CHARLOTTE (nih funded) |
| Locations | 1 site (CHARLOTTE, UNITED STATES) |
| Trial ID | NIH-10894919 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the analysis of gene expression data from bulk tissue samples, particularly in the context of Alzheimer's disease. By using advanced computational algorithms, the study aims to accurately identify differentially expressed genes that are crucial for understanding disease mechanisms. The approach involves deconvoluting complex gene expression data to isolate signals from specific cell types, which can lead to better insights into potential treatments. Patients may benefit from the findings as they could inform the development of targeted therapies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's disease by identifying key genes involved in its progression.
How similar studies have performed: Previous research has shown promise in using computational algorithms for gene expression analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
CHARLOTTE, UNITED STATES
- UNIVERSITY OF NORTH CAROLINA CHARLOTTE — CHARLOTTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, DUAN — UNIVERSITY OF NORTH CAROLINA CHARLOTTE
- Study coordinator: CHEN, DUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease