Developing advanced tests to measure immune responses to influenza vaccines
Official title: A Flexible High-Throughput Immunological Assay to Support Next-Generation Influenza Vaccine Studies
Funded at Meso Scale Diagnostics, LLC · NIH-10836539 · Data updated 2026-11-12
This study is working on better tests to measure the antibodies people make after getting the flu vaccine or being infected with the flu, so we can understand how well the vaccine works and how it protects against different flu strains.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Meso Scale Diagnostics, LLC NIH-funded |
| Lab location | 1 site (Rockville, United States) |
| Project start | May 3, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $837,128 |
| NIH project number | 5UH2AI176136-02 |
| Project ID | NIH-10836539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have recently been vaccinated against influenza or have experienced an influenza infection.
✕Less likely to help
Patients who are not involved in influenza vaccination or infection may not benefit from this research.
What this research studies
This research focuses on creating improved assays to measure the antibodies generated in individuals following influenza infection or vaccination. By utilizing high-throughput multiplexed formats, the study aims to develop tests that can efficiently assess both total antibody responses and the specific antibodies that provide protection against the virus. The assays will leverage the Meso Scale Diagnostics® electrochemiluminescence platform, allowing for simultaneous measurement of antibodies against various influenza strains, which could enhance our understanding of vaccine efficacy and cross-protection.
Why it matters
Potential benefit: If successful, this research could lead to more effective influenza vaccines by providing better insights into immune responses.
How similar studies have gone: Similar approaches have shown success in the qualification of vaccines for other diseases, indicating a promising potential for this novel assay development.
Where this research is happening
-
Meso Scale Diagnostics, LLC
Rockville, United States Active
Researchers
- Principal investigator: Sigal, George B — Meso Scale Diagnostics, LLC
- Study coordinator: Sigal, George B
Related research
Other NIH-funded projects on the same topics.
-
Creating vaccines for influenza and other infectious diseases
This study is all about creating new vaccines to help protect people from the flu and other infections, so patients can look forward to better options for staying healthy.
-
Creating vaccines for human trials against influenza and other infectious diseases
This study is working on creating new vaccines to help protect people from flu and other infectious diseases, including those that could be used in harmful situations, so that everyone can have safer and more effective options to stay healthy.
-
Understanding flu and COVID-19 vaccine responses in people and in the lab
Researchers at Stanford explore how flu and COVID-19 vaccines work in people and in lab tests to improve protection for adults.
-
Surveillance and preparedness for flu and other respiratory pathogens in Kenya
A US-based research grant aims to improve how Kenya detects and prepares for influenza and other respiratory diseases to protect people there and global health.
-
Enhanced Seasonal Influenza Vaccine Targeting Shared and Variable Viral Antigens
A new DNA-based influenza vaccine approach aims to provide both precise protection against circulating strains and broader defense against unexpected strains.
-
How the immune system responds to flu shots and flu infection
This project looks at how adults' immune systems react after flu shots or when they catch the flu to find why some people get better protection than others.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.