Developing advanced technology to modify gut bacteria for better health
A high-performance and versatile technology for precision microbiome engineering
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10840387
This study is exploring a new way to change the bacteria in your gut to help improve digestion and overall health, which could lead to better treatments for conditions related to gut imbalances.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10840387 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a new technology that allows for precise modifications of the gut microbiome, which is crucial for digestion, immunity, and overall health. By utilizing innovative methods like CRISPR and conjugative vectors, the researchers aim to engineer specific bacteria within the gastrointestinal tract to improve their function and balance. This could lead to better understanding and treatment of diseases linked to microbiome imbalances. Patients may benefit from advancements in how gut bacteria are managed and modified to enhance health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with gastrointestinal disorders or those experiencing dysbiosis-related health issues.
Not a fit: Patients with stable gut microbiomes and no gastrointestinal issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore healthy gut microbiomes, potentially improving various health conditions.
How similar studies have performed: Other research has shown promise in microbiome engineering, but this approach is innovative and aims to overcome existing limitations in the field.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, HARRIS H — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: WANG, HARRIS H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.