Developing advanced technology for precise analysis of proteins in individual cells
Official title: Targeted proteomics technology for accurate quantitative single-cell proteomics
Funded at Battelle Pacific Northwest Laboratories · NIH-10911925 · Data updated 2026-11-12
This study is working on a new way to look at proteins in tiny samples, like just a few cancer cells, to help us better understand how cancer and other diseases work, making it easier for doctors to find the right treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | September 23, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $391,207 |
| NIH project number | 5R01GM139858-04 |
| Project ID | NIH-10911925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with tumors that provide limited cellular material for analysis, such as those with rare or small tumors.
✕Less likely to help
Patients with abundant tumor samples or those whose conditions do not involve cellular analysis at the single-cell level may not benefit from this research.
What this research studies
This research focuses on improving the analysis of proteins at the single-cell level, which is essential for understanding cancer biology and other diseases. It aims to overcome current limitations in single-cell proteomics by developing a mass spectrometry-based system that allows for accurate quantification of proteins from very small samples, such as fewer than ten tumor cells. The approach involves addressing challenges related to processing single cells, enhancing sensitivity, and establishing reliable internal standards for measurement. By utilizing advanced technology, this research seeks to provide a more comprehensive view of cellular functions and disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostics and targeted therapies for cancer and other diseases by enabling detailed analysis of individual cells.
How similar studies have gone: Previous research has shown promise in using mass spectrometry for proteomics, but this specific approach to single-cell analysis is relatively novel and untested.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Shi, Tujin — Battelle Pacific Northwest Laboratories
- Study coordinator: Shi, Tujin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.