Developing advanced technologies to modify genes for better understanding of brain function and behavior
CEGS: Center for Synthetic Regulatory Genomics - Renewal
This study is working on new ways to change big parts of DNA to help scientists understand how certain genes work, and it’s aimed at creating special mouse models that can help us learn more about the brain and improve treatments for people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11045787 on NIH RePORTER |
What this research studies
This research focuses on creating innovative technologies to make significant changes to large segments of DNA, which will help scientists explore how regulatory sequences function. By utilizing a pipeline that enhances the design, building, and delivery of these genetic modifications, the project aims to engineer complex genetic landscapes in both cells and animal models. The ultimate goal is to produce highly humanized mouse models that can provide insights into brain function and behavior, potentially leading to advancements in personalized medicine and biotechnology.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with genetic conditions affecting brain function or behavior, as well as those interested in cutting-edge genetic therapies.
Not a fit: Patients with conditions unrelated to genetic regulation or those who do not meet specific genetic criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic influences on brain function and behavior, paving the way for new treatments in personalized medicine.
How similar studies have performed: Previous research has shown promise in genetic engineering and the use of humanized animal models, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Boeke, Jef D — New York University School of Medicine
- Study coordinator: Boeke, Jef D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.