Developing advanced T cell therapies for childhood cancers
Official title: NextGen - CARDIFF
Funded at Cardiff University · NIH-10624984 · Data updated 2026-11-12
This study is working on new ways to use T cell therapies to help kids with solid tumors, like certain types of sarcomas and brain cancers, that current treatments often struggle to treat effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cardiff University NIH-funded |
| Lab location | 1 site (Cardiff, United Kingdom) |
| Project start | June 22, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $138,929 |
| NIH project number | 1OT2CA278656-01 |
| Project ID | NIH-10624984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with solid tumors, particularly sarcomas and brain tumors, who have not responded to current treatment options.
✕Less likely to help
Patients with hematologic malignancies or those whose tumors do not have suitable targets for T cell therapy may not benefit from this research.
What this research studies
This research focuses on creating next-generation T cell therapies specifically designed for treating childhood solid cancers, which current treatments often fail to cure. The approach involves advanced cellular engineering to identify new targets and understand the tumor microenvironment that hinders T cell function. By combining detailed studies of primary tumors with a clinical development program, the research aims to progressively engineer T cells to provide effective treatments for pediatric sarcomas and brain tumors. The goal is to make these engineered therapies a standard treatment option within the next decade.
Why it matters
Potential benefit: If successful, this research could lead to effective and durable treatments for children suffering from solid cancers, significantly improving their chances of recovery.
How similar studies have gone: Other research has shown promise in using engineered T cell therapies for lymphoid cancers, but this approach for pediatric solid tumors is relatively novel and untested.
Where this research is happening
-
Cardiff University
Cardiff, United Kingdom Active
Researchers
- Principal investigator: Sewell, Andrew — Cardiff University
- Study coordinator: Sewell, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.