Developing advanced systems to monitor and support organoids for brain health
Multifunctional 3D Bioelectronic and Microfluidic Hybrid Systems for Online Monitoring, Regulation, and Vascularization of Organoids
This study is working on new technology to help tiny organ models grow better, which could lead to improved treatments for conditions like Alzheimer's disease, ultimately helping patients through more personalized medicine and better drug testing.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-10846669 on NIH RePORTER |
What this research studies
This research focuses on creating innovative 3D bioelectronic and microfluidic systems that can monitor and enhance the growth of organoids, which are miniature organ models derived from stem cells. By integrating various sensors and networks, the project aims to improve the structure and functionality of these organoids, particularly for studying conditions like Alzheimer's disease. Patients may benefit from advancements in personalized medicine and drug testing that arise from more effective organoid models. The approach involves sophisticated techniques to ensure that these organoids can mimic real human tissue more closely, allowing for better research outcomes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with conditions unrelated to neurodegenerative diseases or those who do not have access to advanced medical facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and drug development for Alzheimer's disease and related conditions.
How similar studies have performed: While the integration of bioelectronic and microfluidic systems in organoid research is a novel approach, similar studies have shown promise in enhancing organoid functionality.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Wang, Xueju — University of Connecticut Storrs
- Study coordinator: Wang, Xueju
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.