Developing advanced models to understand RNA behavior and interactions
Next-generation biophysical models for RNA dynamics, ligand binding, and catalysis
This study is exploring new ways to understand the shape and movement of RNA, which is important for many biological functions, to help create better tools and treatments for patients dealing with diseases caused by RNA problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project ID | NIH-10906363 on NIH RePORTER |
What this research studies
This research focuses on creating innovative models to better understand the 3D structure and dynamics of RNA, which plays a crucial role in various biological processes. By utilizing advanced techniques such as cryo-electron microscopy and biochemical assays, the research aims to improve how RNA interacts with small molecules and catalyzes biochemical reactions. The goal is to enhance predictive models that can lead to the development of new RNA-based biosensors and therapeutics, ultimately benefiting patients with diseases linked to RNA dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diseases that involve RNA dysfunction or those who may benefit from RNA-targeted therapies.
Not a fit: Patients with conditions unrelated to RNA dynamics or those not seeking RNA-based treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel RNA-based treatments and diagnostic tools for various diseases.
How similar studies have performed: Other research has shown promise in using advanced modeling techniques for RNA, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Lincoln, United States
- University of Nebraska Lincoln — Lincoln, United States (Active)
Researchers
- Principal investigator: Yesselman, Joseph — University of Nebraska Lincoln
- Study coordinator: Yesselman, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.