Developing advanced models to understand and treat Alzheimer's disease
Official title: Nextgen AD Models, Endotypes, and Screening
Funded at University of California, San Diego · NIH-10885611 · Data updated 2026-11-12
This study is working on making tiny brain models from human cells to learn more about Alzheimer's disease, which could help find better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,319,456 |
| NIH project number | 1RF1AG084030-01A1 |
| Project ID | NIH-10885611 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with familial or late-onset Alzheimer's disease, as well as those at risk for developing the condition.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on creating realistic brain models from human cells to better understand Alzheimer's disease (AD) and its various forms. By developing brain organoids, the team aims to replicate the human brain's response to AD, allowing for a deeper investigation into the disease's mechanisms and progression. The research will also explore different genetic backgrounds associated with AD to identify potential drug targets and screening methods. Patients may benefit from insights gained that could lead to more effective treatments for AD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using human-derived brain models to study neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Subramaniam, Shankar — University of California, San Diego
- Study coordinator: Subramaniam, Shankar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.