Developing advanced miniaturized microscopes for brain imaging
Open-source miniaturized two-photon microscopes for large field-of-view and volumetric imaging
This study is working on making smaller, affordable microscopes that can take clear pictures of brain activity in animals that are moving around, which will help scientists learn more about how the brain works and could eventually lead to better treatments for brain-related conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10868485 on NIH RePORTER |
What this research studies
This research focuses on creating open-source, miniaturized two-photon microscopes that can capture detailed images of brain activity in freely moving animals. By utilizing advanced imaging techniques, the project aims to enhance the field of view and resolution compared to existing technologies, allowing researchers to observe fine structures like dendrites and axons. The goal is to make these sophisticated imaging tools accessible to a wider range of laboratories, thereby democratizing neuroscience research. Patients may benefit indirectly through advancements in understanding brain function and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with neurological conditions or those interested in the underlying mechanisms of brain function.
Not a fit: Patients with conditions unrelated to brain function or those not involved in research settings may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in our understanding of brain function and the development of new treatments for neurological conditions.
How similar studies have performed: Previous research has shown success with similar miniaturized imaging technologies, indicating a promising path for this innovative approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Golshani, Peyman — University of California Los Angeles
- Study coordinator: Golshani, Peyman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.