Developing advanced liver models for drug testing
MPS Resources Section
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11003756
This study is working on creating tiny models of the human liver to help test new drugs more safely and effectively, which could lead to better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11003756 on ClinicalTrials.gov |
What this research studies
This research focuses on creating and validating patient-derived liver microphysiology systems (MPS) that mimic human liver function for use in drug development. The project aims to establish quality control and validation processes for these systems, ensuring they can be reliably used in clinical settings. Patients may benefit from this research as it seeks to improve drug testing methods, potentially leading to safer and more effective treatments. The research involves collaboration with various partners to enhance the technology and resources used in the development of these systems.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with liver conditions, particularly those related to obesity and fatty liver disease.
Not a fit: Patients without liver conditions or those not involved in drug development processes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer drug therapies for patients with liver-related conditions.
How similar studies have performed: Other research has shown promise in using biomimetic systems for drug testing, indicating that this approach could be effective.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VERNETTI, LAWRENCE A — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: VERNETTI, LAWRENCE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.