Developing advanced imaging technology for analyzing cells in 3D at high speeds
Three-dimensional fluorescence imaging flow cytometry at up to million frames per second
This study is working on a new way to look at cells in 3D really quickly, which could help scientists learn more about how cells behave and what they look like, making it easier to study many cells at once.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11004073 on NIH RePORTER |
What this research studies
This research focuses on enhancing flow cytometry by developing a new imaging technique that allows for three-dimensional analysis of cells at unprecedented speeds. The approach combines the rapid analysis capabilities of traditional flow cytometry with advanced microscopy to capture detailed 3D images of cellular structures. By utilizing a novel method called Line Excitation Array Detection microscopy (LEAD), the researchers aim to overcome current limitations in resolution and field of view, enabling the analysis of hundreds to thousands of cells simultaneously. This could significantly improve our understanding of cellular behavior and characteristics in various biological contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that require detailed cellular analysis, such as cancer or other diseases affecting cell behavior.
Not a fit: Patients with conditions that do not involve cellular analysis or those who are not undergoing treatment that requires such detailed imaging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment strategies for various diseases, including cancer.
How similar studies have performed: While imaging flow cytometry has been explored, this specific approach using LEAD microscopy represents a novel advancement that has not been extensively tested in prior studies.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Ben-Yakar, Adela — University of Texas at Austin
- Study coordinator: Ben-Yakar, Adela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.