Developing advanced human airway models to study immune responses to viral infections
Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infection
This study is working on making detailed 3D models of human lungs to see how our immune system reacts to viruses, especially as we get older, so we can learn more about respiratory diseases and improve treatments for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11059974 on NIH RePORTER |
What this research studies
This research aims to create sophisticated three-dimensional (3D) models of human airways to better understand how the immune system interacts with lung cells during viral infections. By using bioprinting technology, the project will develop ventilated and vascularized lung models that mimic real human tissue. This approach will allow researchers to investigate the complex interactions between immune cells and lung epithelial cells, particularly how these interactions change with age. The goal is to overcome current limitations in studying human lung immunity and improve our understanding of respiratory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with respiratory conditions or those interested in how age affects lung immunity.
Not a fit: Patients with non-respiratory conditions or those who are not affected by age-related changes in lung function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for respiratory infections, particularly in aging populations.
How similar studies have performed: Other research has shown promise in using 3D models to study immune responses, indicating that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Williams, Adam — Jackson Laboratory
- Study coordinator: Williams, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.