Developing advanced genetic tests to understand human health variations
Recombinant DNA technologies for multiplex genetic assays in human cells
This study is working on new ways to look at many genetic differences in our cells at once, which could help us understand how these differences affect our health and lead to more personalized treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11092728 on NIH RePORTER |
What this research studies
This research focuses on creating innovative genetic assays that can analyze multiple genetic variants simultaneously within human cells. By utilizing advanced synthetic biology tools, the project aims to improve the efficiency and usability of these assays, which are essential for linking genetic variations to health outcomes. The approach involves using a specific bacteriophage DNA recombinase to facilitate the expression of complex variant libraries, allowing for a more comprehensive understanding of how these variants affect human health. Patients may benefit from the insights gained through this research, which could lead to better personalized medicine strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations that have not yet been fully characterized or understood in relation to their health.
Not a fit: Patients with well-characterized genetic conditions that already have established treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic variations and their impact on health, leading to more personalized and effective treatments.
How similar studies have performed: Other research has shown promise in using multiplex genetic assays to uncover the effects of genetic variants, indicating that this approach could be a significant advancement in the field.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Matreyek, Kenneth a — Case Western Reserve University
- Study coordinator: Matreyek, Kenneth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.