Developing advanced gene circuits for controlling immune cell functions
Synthetic circuit technologies for precision control and signal processing in mammalian cells
['FUNDING_R01'] · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · NIH-11167739
This study is working on new ways to help your immune cells, like T cells and macrophages, work better at fighting diseases, including cancer, by giving them special instructions to recognize and respond to different targets in your body, which could lead to improved treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11167739 on ClinicalTrials.gov |
What this research studies
This research focuses on creating synthetic gene circuits that allow for precise control of gene regulation and the functions of human immune cells, particularly T cells and macrophages. By utilizing innovative engineering toolkits, the project aims to enhance the ability of these cells to recognize and respond to various targets in the body, potentially leading to more effective cell-based therapies. The approach includes programming immune cells to perform complex therapeutic actions, which could significantly improve treatment outcomes for patients with various conditions, including cancers. The research is positioned to advance the development of next-generation cellular therapies through clinical trials.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with cancers or other conditions that could be treated with advanced immune cell therapies.
Not a fit: Patients with conditions unrelated to immune function or those who do not qualify for cell-based therapies may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with immune-related conditions and cancers.
How similar studies have performed: Other research has shown promise in using synthetic gene circuits for immune cell therapies, indicating a potential for success in this innovative approach.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHALIL, AHMAD SAMIR — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- Study coordinator: KHALIL, AHMAD SAMIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.