Developing Advanced Cell Models for Alzheimer's Disease
Human iPSC Models Core
This project creates special human cell models from patients to better understand how a gene called APOE contributes to Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11105811 on NIH RePORTER |
What this research studies
Researchers are creating advanced cell models using induced pluripotent stem cells (iPSCs), which are special cells that can turn into many different types of cells. These iPSCs are grown from patient samples and can be guided to become brain cells like neurons, astrocytes, and microglia, or even tiny 3D 'mini-brains' called cerebral organoids. By using cells from patients with different APOE gene types, sexes, and ethnicities, scientists can explore how this gene affects brain cells and contributes to the early stages of Alzheimer's disease. This work helps us learn more about the disease process in a human-relevant way.
Who could benefit from this research
Good fit: This project uses existing cell samples from patients with Alzheimer's disease who have well-documented health information and known APOE gene types.
Not a fit: Patients who do not have Alzheimer's disease or those not interested in foundational cellular research may not directly benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Alzheimer's disease at a cellular level, potentially identifying new targets for future treatments.
How similar studies have performed: While human iPSC models are a well-established tool in research, this project aims to create a uniquely comprehensive collection of cell lines to specifically address the complex role of APOE in Alzheimer's disease.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Karch, Celeste Marie — Mayo Clinic Jacksonville
- Study coordinator: Karch, Celeste Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.