Developing advanced biosensors to study cancer and immune cell interactions
Ultrasensitive kinase biosensors for multiplex imaging of coordinated spatiotemporal signaling in cancer-immune interactions
This study is working on new tools to see how important proteins behave in living cells, which could help us understand cancer better and find better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10884919 on NIH RePORTER |
What this research studies
This research focuses on creating highly sensitive biosensors that can detect and visualize protein kinases, which are crucial for understanding cellular functions in cancer and immune interactions. By using advanced imaging techniques, the project aims to observe how these signaling enzymes behave in real-time within living cells. The interdisciplinary team combines expertise in biosensor technology and bioengineering to enhance our understanding of cancer biology and improve therapeutic strategies. Patients may benefit from insights gained through this research that could lead to more effective cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who may benefit from improved therapeutic strategies targeting cancer-immune interactions.
Not a fit: Patients with non-cancerous conditions or those not involved in immune signaling may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in cancer treatment by providing new insights into how cancer cells communicate with immune cells.
How similar studies have performed: Previous research has shown success in using biosensors for studying cellular signaling, indicating a promising avenue for this innovative approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Zhang, Jin — University of California, San Diego
- Study coordinator: Zhang, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.